After the Hussite invasion in 15th. century, the cathedral remained in ruins, yet had such a monumental impact that in 1681 it was named “Splendissima Basilica” – the most magnificent basilica. At the turn of the 17th 17. and 18th centuries the cathedral was rebuilt by the Cistercian order in the Baroque-Gothic style of Jan Blažej Santini-Aichl. He wove unique self-supporting building elements into the building – a vault called “the Czech sail vault” (česká placka) and a spiral staircase. After the dissolution of the Sedlec Monastery by Joseph II and the establishment of a tobacco factory in its former buildings, the cathedral began to serve as a Roman Catholic parish church.

In the church we can find precious artistic monuments, such as paintings by Peter Brandl, Michael Leopold Willmann, Jan Krystof Liška, etc. The cathedral has an accessible first attic, through which it is possible to go up to the choir of the west façade. The church treasury contains one of the most precious jewels of Central Europe – the original Sedlec monstrance. According to recent findings, it is one of the oldest surviving Gothic monstrances in the world.